Updated: 12/12/06 08:23 AM

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The first job in evaluating such patients is to obtain as many clues from the history and physical as possible. Some patients have a history of loose stools or a history of adult-onset diabetes. Other common presenting symptoms can include upper abdominal pain radiating through to the back, malabsorption, and/or weight loss. Occasionally patients will have lower abdominal pain; this symptom coupled with diarrhea may lead to evaluation of their colon rather than their pancreas. Symptoms of the patient can be compared with symptoms of other affected family members. Many patients will have a positive family history but have no symptoms at all.