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Rachel B. Issaka, MD, MAS
Assistant Professor & Assistant Member,
Fred Hutchinson Cancer Research Center

​Dr. Issaka is a gastroenterologist at the Fred Hutchinson Cancer Research Center and the University of Washington. She specializes in the medical and endoscopic management of digestive diseases including cancer complications that affect the gastrointestinal system.

Dr. Issaka completed her gastroenterology fellowship at the University of California, San Francisco, internal medicine residency and chief residency at Northwestern University, and medical school at the University of Michigan.
In addition to working with patients with digestive diseases, Dr. Issaka is a health services researcher with the Hutchinson Institute for Cancer Outcomes Research (HICOR). She obtained a Master of Advanced Studies in Clinical Research degree from the University of California, San Francisco and conducts research related to colon cancer screening, prevention, and implementation of interventions that decrease disparities and improve outcomes in colorectal cancer care.
Recent Publications
Displaying 20 Most Recent Publications from PubMed

June 2019. Effectiveness and cost of organized outreach for colorectal cancer screening: A Randomized Controlled Trial. Somsouk M, Rachocki C, Mannalithara A, Garcia D, Laleau V, Grimes B, Issaka RB, Chen E, Vittinghoff E, Shapiro JA, Ladabaum U. J Natl Cancer Inst. 2019 Jun 12. pii: djz110. doi: 10.1093/jnci/djz110. [Epub ahead of print]

December 2018. Low-Value Colorectal Cancer Screening: Too Much of a Good Thing? Issaka RB, Inadomi JM. JAMA Netw Open. 2018 Dec 7;1(8):e185445. doi: 10.1001/jamanetworkopen.2018.5445.

November 2018. Low-literacy Level Instructions and Reminder Calls Improve Patient Handling of Fecal Immunochemical Test Samples. Wang A, Rachocki C, Shapiro JA, Issaka RB, Somsouk M. Clin Gastroenterol Hepatol. 2018 Nov 29. pii: S1542-3565(18)31327-2. doi: 10.1016/j.cgh.2018.11.050. [Epub ahead of print]

October 2018. Population health interventions to improve colorectal cancer screening by fecal immunochemical tests: A systematic review. Issaka RB, Avila P, Whitaker E, Bent S, Somsouk M. Prev Med. 2018 Oct 24. pii: S0091-7435(18)30340-2. doi: 10.1016/j.ypmed.2018.10.021. [Epub ahead of print]

April 2018. Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light. Alsayid M, Singh MH, Issaka R, Laleau V, Day L, Lee J, Allison J, Somsouk M. Clin Gastroenterol Hepatol. 2018 Apr 13. pii: S1542-3565(18)30370-7. doi: 10.1016/j.cgh.2018.04.014. [Epub ahead of print]

January 2018. Missed Opportunities in Colorectal Cancer Prevention in Patients with Inadequate Bowel Preparations. Issaka RB, Singh MH, Rachocki C, Day LW, Horton C, Somsouk M. Clin Gastroenterol Hepatol. 2018 Jan 9. pii: S1542-3565(18)30014-4. doi: 10.1016/j.cgh.2018.01.004. [Epub ahead of print]

February 2017. Inadequate Utilization of Diagnostic Colonoscopy Following Abnormal FIT Results in an Integrated Safety-Net System. Issaka RB, Singh MH, Oshima SM, Laleau VJ, Rachocki CD, Chen EH, Day LW, Sarkar U, Somsouk M. Am J Gastroenterol. 2017 Feb;112(2):375-382. doi: 10.1038/ajg.2016.555. Epub 2016 Dec 13.

March 2016. Reply. Ravi K, Friesen L, Issaka R, Kahrilas PJ, Pandolfino JE. Clin Gastroenterol Hepatol. 2016 Mar;14(3):481-2. doi: 10.1016/j.cgh.2015.12.011. Epub 2015 Dec 10.

August 2015. Long-term Outcomes of Patients With Normal or Minor Motor Function Abnormalities Detected by High-resolution Esophageal Manometry. Ravi K, Friesen L, Issaka R, Kahrilas PJ, Pandolfino JE. Clin Gastroenterol Hepatol. 2015 Aug;13(8):1416-23. doi: 10.1016/j.cgh.2015.02.046. Epub 2015 Mar 11.

May 2014. Palliative venting percutaneous endoscopic gastrostomy tube is safe and effective in patients with malignant obstruction. Issaka RB, Shapiro DM, Parikh ND, Mulcahy MF, Komanduri S, Martin JA, Keswani RN. Surg Endosc. 2014 May;28(5):1668-73. doi: 10.1007/s00464-013-3368-7. Epub 2013 Dec 24.

April 2014. Inpatient weekend ERCP is associated with a reduction in patient length of stay. Parikh ND, Issaka R, Lapin B, Komanduri S, Martin JA, Keswani RN. Am J Gastroenterol. 2014 Apr;109(4):465-70. doi: 10.1038/ajg.2013.362.

October 2009. Vascular endothelial growth factors C and D induces proliferation of lymphangioleiomyomatosis cells through autocrine crosstalk with endothelium. Issaka RB, Oommen S, Gupta SK, Liu G, Myers JL, Ryu JH, Vlahakis NE. Am J Pathol. 2009 Oct;175(4):1410-20. doi: 10.2353/ajpath.2009.080830. Epub 2009 Aug 28.

May 2007. Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. Vlahakis NE, Young BA, Atakilit A, Hawkridge AE, Issaka RB, Boudreau N, Sheppard D. J Biol Chem. 2007 May 18;282(20):15187-96. Epub 2007 Mar 14.

February 2007. Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5. Oestreich AJ, Aboian M, Lee J, Azmi I, Payne J, Issaka R, Davies BA, Katzmann DJ. Mol Biol Cell. 2007 Feb;18(2):707-20. Epub 2006 Dec 20.

Contact Info

MAS, Clinical Research, University of California, San Francisco, San Francisco, CA

Fellowship, Gastroenterology, University of California, San Francisco, San Francisco, CA

Residency, Internal Medicine, Northwestern University, McGraw Medical Center, Chicago, IL 

​Internship, Internal Medicine, Northwestern University, McGraw Medical Center, Chicago, IL

MD, University of Michigan Medical School, Ann Arbor, MI

BS, Biology, University of Wisconsin, Eua Claire, WI

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