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Brian J. Reid, MD, PhD
Professor & Adjunct Professor, Department of Genetics
Member, Fred Hutchinson Cancer Research Center

Dr. Reid is the Founder and Director of the Seattle Barrett's Esophagus Study (the Seattle Study). As an undergraduate and graduate student in Genetics, he and Lee Hartwell discovered yeast cell cycle mutations which led to basic research that proposed the first genetic model of eukaryotic cell division. This model became the basis for Lee Hartwell's well deserved Nobel Prize in 2001.

After graduate school, Dr. Reid entered medical school to study neoplastic evolution with the goal of improving care for patients who are at risk for or have cancer. He has been investigating Barrett's esophagus since 1983.

The goal of Dr. Reid's work on Barrett's esophagus is to understand the mechanisms by which environmental exposures (i.e. aspirin or other nonsteroidal antiinflammatory agents) affect the evolution of clones that lead to the development of esophageal adenocarcinoma in patients with Barrett's esophagus.

Recent research in the Seattle Study, and other studies around the world, indicate that attempts to reduce mortality of esophageal adenocarcinoma are limited by overdiagnosis of benign Barrett's that remains stable for the lifetime of an individual and underdiagnosis of life-threatening early esophageal adenocarcinoma.

The Seattle Study is testing the hypothesis that these different disease dynamics are the result of clonal evolutionary dynamics that cause length bias. This understanding can then be used to develop interventions to prevent progression to cancer or to detect the cancers and premalignant abnormalities when they are early and curable, while avoiding invasive and costly interventions that cause significant adverse events in individuals who have little reason to expect benefit because their risk of cancer is low.

Recent Publications
Displaying 20 Most Recent Publications from PubMed

March 2019. Correction to: NSAID use and somatic exomic mutations in Barrett's esophagus. Galipeau PC, Oman KM, Paulson TG, Sanchez CA, Zhang Q, Marty JA, Delrow JJ, Kuhner MK, Vaughan TL, Reid BJ, Li X. Genome Med. 2019 Mar 12;11(1):14. doi: 10.1186/s13073-019-0625-y.

February 2019. No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma-a Mendelian Randomization Study. Dong J, Gharahkhani P, Chow WH, Gammon MD, Liu G, Caldas C, Wu AH, Ye W, Onstad L, Anderson LA, Bernstein L, Pharoah PD, Risch HA, Corley DA, Fitzgerald RC; Stomach and Esophageal Cancer Study (SOCS) Consortium, Iyer PG, Reid BJ, Lagergren J, Shaheen NJ, Vaughan TL, MacGregor S, Love S, Palles C, Tomlinson I, Gockel I, May A, Gerges C, Anders M, Böhmer AC, Becker J, Kreuser N, Thieme R, Noder T, Venerito M, Veits L, Schmidt T, Schmidt C, Izbicki JR, Hölscher AH, Lang H, Lorenz D, Schumacher B, Mayershofer R, Vashist Y, Ott K, Vieth M, Weismüller J, Nöthen MM, Moebus S, Knapp M, Peters WHM, Neuhaus H, Rösch T, Ell C, Jankowski J, Schumacher J, Neale RE, Whiteman DC, Thrift AP. Clin Gastroenterol Hepatol. 2019 Feb 1. pii: S1542-3565(19)30088-6. doi: 10.1016/j.cgh.2019.01.041. [Epub ahead of print]

March 2018. Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus. Dong J, Levine DM, Buas MF, Zhang R, Onstad L, Fitzgerald RC; Stomach and Oesophageal Cancer Study (SOCS) consortium, Corley DA, Shaheen NJ, Lagergren J, Hardie LJ, Reid BJ, Iyer PG, Risch HA, Caldas C, Caldas I, Pharoah PD, Liu G, Gammon MD, Chow WH, Bernstein L, Bird NC, Ye W, Wu AH, Anderson LA, MacGregor S, Whiteman DC, Vaughan TL, Thrift AP. Clin Gastroenterol Hepatol. 2018 Mar 15. pii: S1542-3565(18)30262-3. doi: 10.1016/j.cgh.2018.03.007. [Epub ahead of print]

February 2018. NSAID use and somatic exomic mutations in Barrett's esophagus. Galipeau PC, Oman KM, Paulson TG, Sanchez CA, Zhang Q, Marty JA, Delrow JJ, Kuhner MK, Vaughan TL, Reid BJ, Li X. Genome Med. 2018 Feb 27;10(1):17. doi: 10.1186/s13073-018-0520-y.

February 2018. Evolution of Barrett's esophagus through space and time at single-crypt and whole-biopsy levels. Martinez P, Mallo D, Paulson TG, Li X, Sanchez CA, Reid BJ, Graham TA, Kuhner MK, Maley CC. Nat Commun. 2018 Feb 23;9(1):794. doi: 10.1038/s41467-017-02621-x.

December 2017. Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants. Dong J, Buas MF, Gharahkhani P, Kendall BJ, Onstad L, Zhao S, Anderson LA, Wu AH, Ye W, Bird NC, Bernstein L, Chow WH, Gammon MD, Liu G, Caldas C, Pharoah PD, Risch HA, Iyer PG, Reid BJ, Hardie LJ, Lagergren J, Shaheen NJ, Corley DA, Fitzgerald RC; Stomach and Oesophageal Cancer Study (SOCS) consortium, Whiteman DC, Vaughan TL, Thrift AP. Gastroenterology. 2017 Dec 13. pii: S0016-5085(17)36691-X. doi: 10.1053/j.gastro.2017.12.003. [Epub ahead of print]

August 2017. Early Diagnosis of Gastroesophageal Cancers and the Cytosponge: A Work in Progress. Fitzgerald RC, Reid BJ. Cell Mol Gastroenterol Hepatol. 2017 Aug 14;4(3):447. doi: 10.1016/j.jcmgh.2017.07.004. eCollection 2017 Nov.

June 2017. Quantification of Multiple Tumor Clones Using Gene Array and Sequencing Data. Cheng Y, Dai JY, Paulson TG, Wang X, Li X, Reid BJ, Kooperberg C. Ann Appl Stat. 2017 Jun;11(2):967-991. doi: 10.1214/17-AOAS1026. Epub 2017 Jul 20.

March 2017. Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett's esophagus, and high-grade dysplasia/esophageal adenocarcinoma. Buas MF, Gu H, Djukovic D, Zhu J, Onstad L, Reid BJ, Raftery D, Vaughan TL. Metabolomics. 2017 Mar;13(3). pii: 23. doi: 10.1007/s11306-016-1154-y.

February 2017. Genomics, Endoscopy, and Control of Gastroesophageal Cancers: A Perspective. Reid BJ. Cell Mol Gastroenterol Hepatol. 2017 Feb 20;3(3):359-366. doi: 10.1016/j.jcmgh.2017.02.005. eCollection 2017 May.

September 2016. Research Needs for Understanding the Biology of Overdiagnosis in Cancer Screening. Srivastava S, Reid BJ, Ghosh S, Kramer BS. J Cell Physiol. 2016 Sep;231(9):1870-5. doi: 10.1002/jcp.25227. Epub 2016 Apr 29.

July 2016. Surrogate Markers: Lessons from the Next Gen? Reid BJ. Cancer Prev Res (Phila). 2016 Jul;9(7):512-7. doi: 10.1158/1940-6207.CAPR-16-0059. Epub 2016 May 2.

March 2016. Limitations of the driver/passenger model in cancer prevention. Kuhner MK, Kostadinov R, Reid BJ. Cancer Prev Res (Phila). 2016 Mar 1. pii: canprevres.0343.2015.

December 2015. Forty-five years of cell-cycle genetics. Reid BJ, Culotti JG, Nash RS, Pringle JR. Mol Biol Cell. 2015 Dec 1;26(24):4307-12. doi: 10.1091/mbc.E14-10-1484.

November 2015. A newly identified susceptibility locus near FOXP1 modifies the association of gastroesophageal reflux with Barrett's esophagus. Dai JY, Tapsoba JD, Buas MF, Onstad LE, Levine DM, Risch HA, Chow WH, Bernstein L, Ye W, Lagergren J, Bird NC, Corley DA, Shaheen NJ, Wu AH, Reid BJ, Hardie LJ, Whiteman DC, Vaughan TL. Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1739-47. doi: 10.1158/1055-9965.EPI-15-0507. Epub 2015 Sep 16.

October 2015. Genetic Insights in Barrett's Esophagus and Esophageal Adenocarcinoma. Reid BJ, Paulson TG, Li X. Gastroenterology. 2015 Oct;149(5):1142-1152.e3. doi: 10.1053/j.gastro.2015.07.010. Epub 2015 Jul 21.

September 2015. Assessment of esophageal adenocarcinoma risk using somatic chromosome alterations in longitudinal samples in Barrett's esophagus. Li X, Paulson TG, Galipeau PC, Sanchez CA, Liu K, Kuhner MK, Maley CC, Self SG, Vaughan TL, Reid BJ, Blount PL. Cancer Prev Res (Phila). 2015 Sep;8(9):845-56. doi: 10.1158/1940-6207.CAPR-15-0130. Epub 2015 Jun 30.

September 2015. Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett's esophagus. Hardikar S, Song X, Risques RA, Montine TJ, Duggan C, Blount PL, Reid BJ, Anderson GL, Kratz M, White E, Vaughan TL. BMC Obes. 2015 Sep 10;2:32. doi: 10.1186/s40608-015-0063-3. eCollection 2015.

September 2015. Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium. Lagergren K, Ek WE, Levine D, Chow WH, Bernstein L, Casson AG, Risch HA, Shaheen NJ, Bird NC, Reid BJ, Corley DA, Hardie LJ, Wu AH, Fitzgerald RC, Pharoah P, Caldas C, Romero Y, Vaughan TL, MacGregor S, Whiteman D, Westberg L, Nyren O, Lagergren J. PLoS One. 2015 Sep 25;10(9):e0138738. doi: 10.1371/journal.pone.0138738. eCollection 2015.

July 2015. High Goblet Cell Count Is Inversely Associated with Ploidy Abnormalities and Risk of Adenocarcinoma in Barrett's Esophagus. Srivastava A, Golden KL, Sanchez CA, Liu K, Fong PY, Li X, Cowan DS, Rabinovitch PS, Reid BJ, Blount PL, Odze RD. PLoS One. 2015 Jul 31;10(7):e0133403. doi: 10.1371/journal.pone.0133403. eCollection 2015.

June 2015. Bacterial Composition of the Human Upper Gastrointestinal Tract Microbiome Is Dynamic and Associated with Genomic Instability in a Barrett's Esophagus Cohort. Gall A, Fero J, McCoy C, Claywell BC, Sanchez CA, Blount PL, Li X, Vaughan TL, Matsen FA, Reid BJ, Salama NR. PLoS One. 2015 Jun 15;10(6):e0129055. doi: 10.1371/journal.pone.0129055. eCollection 2015.

June 2015. MiRNA-Related SNPs and Risk of Esophageal Adenocarcinoma and Barrett's Esophagus: Post Genome-Wide Association Analysis in the BEACON Consortium. Buas MF, Onstad L, Levine DM, Risch HA, Chow WH, Liu G, Fitzgerald RC, Bernstein L, Ye W, Bird NC, Romero Y, Casson AG, Corley DA, Shaheen NJ, Wu AH, Gammon MD, Reid BJ, Hardie LJ, Peters U, Whiteman DC, Vaughan TL. PLoS One. 2015 Jun 3;10(6):e0128617. doi: 10.1371/journal.pone.0128617. eCollection 2015.

February 2015. Polymorphisms Near TBX5 and GDF7 are Associated with Increased Risk for Barrett's Esophagus. Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Giner FC, Peppelenbosch MP, Kovac M, Adams CL, Prenen H, Briggs S, Harrison R, Sanders S, MacDonald D, Haigh C, Tucker A, Love S, Nanji M, deCaestecker J, Ferry D, Rathbone B, Hapeshi J, Barr H, Zietek B, Maroo N, Gay L, Underwood T, Boulter L, McMurtry H, Monk D, Patel P, Ragunath K, Al Dulaimi D, Murray I, Koss K, Veitch A, Trudgill N, Nwokolo C, Rembacken B, Atherfold P, Green E, Ang Y, Kuipers EJ, Chow W, Paterson S, Kadri S, Beales I, Grimley C, Mullins P, Beckett C, Farrant M, Dixon A, Kelly S, Johnson M, Wajed S, Dhar A, Sawyer E, Roylance R, Onstad L, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Reid BJ, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Fitzgerald R, Whiteman DC, Risch HA, Levine DM, Vaughan TL, Verhaar AP, van den Brande J, Toxopeus EL, Spaander MC, Wijnhoven BP, van der Laan LJ, Krishnadath K, Wijmenga C, Trynka G, McManus R, Reynolds JV, O'Sullivan J, MacMathuna P, McGarrigle SA, Kelleher D, Vermeire S, Cleynen I, Bisschops R, Tomlinson I, Jankowski J. Gastroenterology. 2015 Feb;148(2):367-78. doi: 10.1053/j.gastro.2014.10.041. Epub 2014 Nov 5.

December 2014. Integrative post genome-wide association analysis of CDKN2A and TP53 SNPs and risk of esophageal adenocarcinoma. Buas MF, Levine DM, Makar KW, Utsugi H, Onstad L, Li X, Galipeau PC, Shaheen NJ, Hardie LJ, Romero Y, Bernstein L, Gammon MD, Casson AG, Bird NC, Risch HA, Ye W, Liu G, Corley DA, Blount PL, Fitzgerald RC, Whiteman DC, Wu AH, Reid BJ, Vaughan TL. Carcinogenesis. 2014 Dec;35(12):2740-7. doi: 10.1093/carcin/bgu207. Epub 2014 Oct 3.

November 2014. Inflammation and oxidative stress markers and esophageal adenocarcinoma incidence in a Barrett's esophagus cohort. Hardikar S, Onstad L, Song X, Wilson AM, Montine TJ, Kratz M, Anderson GL, Blount PL, Reid BJ, White E, Vaughan TL. Cancer Epidemiol Biomarkers Prev. 2014 Nov;23(11):2393-403. doi: 10.1158/1055-9965.EPI-14-0384. Epub 2014 Aug 8.

October 2014. Risk of Esophageal Adenocarcinoma Decreases with Height, Based on Consortium Analysis and Confirmed by Mendelian Randomization. Thrift AP, Risch HA, Onstad L, Shaheen NJ, Casson AG, Bernstein L, Corley DA, Levine DM, Chow WH, Reid BJ, Romero Y, Hardie LJ, Liu G, Wu AH, Bird NC, Gammon MD, Ye W, Whiteman DC, Vaughan TL. Clin Gastroenterol Hepatol. 2014 Oct;12(10):1667-76.e1. doi: 10.1016/j.cgh.2014.01.039. Epub 2014 Feb 12.

September 2014. Obesity and Risk of Esophageal Adenocarcinoma and Barrett's Esophagus: A Mendelian Randomization Study. Thrift AP, Shaheen NJ, Gammon MD, Bernstein L, Reid BJ, Onstad L, Risch HA, Liu G, Bird NC, Wu AH, Corley DA, Romero Y, Chanock SJ, Chow WH, Casson AG, Levine DM, Zhang R, Ek WE, MacGregor S, Ye W, Hardie LJ, Vaughan TL, Whiteman DC. J Natl Cancer Inst. 2014 Sep 30;106(11). pii: dju252. doi: 10.1093/jnci/dju252. Print 2014 Nov.

March 2014. Quantification of population benefit in evaluation of biomarkers: practical implications for disease detection and prevention. Li X, Blount PL, Reid BJ, Vaughan TL. BMC Med Inform Decis Mak. 2014 Mar 6;14:15. doi: 10.1186/1472-6947-14-15.

January 2014. Changing the terminology of cancer--reply. Esserman LJ, Thompson IM, Reid BJ. JAMA. 2014 Jan 8;311(2):203. doi: 10.1001/jama.2013.283385.

January 2014. Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus. Li X, Galipeau PC, Paulson TG, Sanchez CA, Arnaudo J, Liu K, Sather CL, Kostadinov RL, Odze RD, Kuhner MK, Maley CC, Self SG, Vaughan TL, Blount PL, Reid BJ. Cancer Prev Res (Phila). 2014 Jan;7(1):114-27. doi: 10.1158/1940-6207.CAPR-13-0289. Epub 2013 Nov 19.

Contact Info

M.D., University of Washington, Seattle, WA

Ph.D. in Genetics, University of Washington, Seattle, WA

Residency in Medicine, Brigham and Women's Hospital, Boston, MA

Fellowship in Gastroenterology, University of Washington, Seattle, WA

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