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Tatiana Khokhlova, PhD
Research Assistant Professor

Dr. Tatiana (Tanya) Khokhlova is an Assistant Professor of Research who specializes in ultrasound technology for cancer diagnostics and therapy.

She joined UWGI faculty as Acting Instructor in 2012 after completing her PhD in Physics from Moscow State University (Moscow, Russia) and postdoctoral training at the University of Washington. Dr. Khokhlova’s current research projects are primarily aimed at developing ultrasound-based non-invasive interventions for treatment of pancreas cancer termed pulsed focused ultrasound (pFUS) and translating these interventions and associated devices from pre-clinical studies to clinical trials. Other ongoing projects span a wide range of clinical targets, including minimally invasive evacuation of large traumatic hematomas, using ultrasound to stimulate the release of cancer biomarkers and non-invasive ablation options for benign prostate hyperplasia. This research is done in close collaboration with Center for Industrial and Medical Ultrasound (Applied Physics Lab, University of Washington).

Recent Publications
Displaying 20 Most Recent Publications from PubMed

December 2018. Mechanical decellularization of tissue volumes using boiling histotripsy. Wang YN, Khokhlova TD, Buravkov S, Chernikov V, Kreider W, Partanen A, Farr N, Maxwell A, Schade GR, Khokhlova VA. Phys Med Biol. 2018 Dec 4;63(23):235023. doi: 10.1088/1361-6560/aaef16.

October 2018. Boiling Histotripsy Ablation of Renal Cell Carcinoma in the Eker Rat Promotes a Systemic Inflammatory Response. Schade GR, Wang YN, D'Andrea S, Hwang JH, Liles WC, Khokhlova TD. Ultrasound Med Biol. 2018 Oct 16. pii: S0301-5629(18)30403-4. doi: 10.1016/j.ultrasmedbio.2018.09.006. [Epub ahead of print]

November 2017. Focused ultrasound for immuno-adjuvant treatment of pancreatic cancer: An emerging clinical paradigm in the era of personalized oncotherapy. Maloney E, Khokhlova T, Pillarisetty VG, Schade GR, Repasky EA, Wang YN, Giuliani L, Spring M, Hwang JH. Int Rev Immunol. 2017 Nov 2;36(6):338-351. doi: 10.1080/08830185.2017.1363199. Epub 2017 Sep 29.

October 2017. A Prototype Therapy System for Transcutaneous Application of Boiling Histotripsy. Maxwell AD, Yuldashev PV, Kreider W, Khokhlova TD, Schade GR, Hall TL, Sapozhnikov OA, Bailey MR, Khokhlova VA. IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Oct;64(10):1542-1557. doi: 10.1109/TUFFC.2017.2739649. Epub 2017 Aug 14.

September 2017. Dependence of Boiling Histotripsy Treatment Efficiency on HIFU Frequency and Focal Pressure Levels. Khokhlova TD, Haider YA, Maxwell AD, Kreider W, Bailey MR, Khokhlova VA. Ultrasound Med Biol. 2017 Sep;43(9):1975-1985. doi: 10.1016/j.ultrasmedbio.2017.04.030. Epub 2017 Jun 20.

April 2017. Release of Cell-free MicroRNA Tumor Biomarkers into the Blood Circulation with Pulsed Focused Ultrasound: A Noninvasive, Anatomically Localized, Molecular Liquid Biopsy. Chevillet JR, Khokhlova TD, Giraldez MD, Schade GR, Starr F, Wang YN, Gallichotte EN, Wang K, Hwang JH, Tewari M. Radiology. 2017 Apr;283(1):158-167. doi: 10.1148/radiol.2016160024. Epub 2016 Nov 1.

July 2016. Histotripsy Liquefaction of Large Hematomas. Khokhlova TD, Monsky WL, Haider YA, Maxwell AD, Wang YN, Matula TJ. Ultrasound Med Biol. 2016 Jul;42(7):1491-8. doi: 10.1016/j.ultrasmedbio.2016.01.020. Epub 2016 Apr 25.

April 2016. Enhancement of Small Molecule Delivery by Pulsed High-Intensity Focused Ultrasound: A Parameter Exploration. Zhou Y, Wang YN, Farr N, Zia J, Chen H, Ko BM, Khokhlova T, Li T, Hwang JH. Ultrasound Med Biol. 2016 Apr;42(4):956-63. doi: 10.1016/j.ultrasmedbio.2015.12.009. Epub 2016 Jan 21.

November 2015. Therapeutic potential of ultrasound microbubbles in gastrointestinal oncology: recent advances and future prospects. Khokhlova TD, Haider Y, Hwang JH. Therap Adv Gastroenterol. 2015 Nov;8(6):384-94. doi: 10.1177/1756283X15592584. Review.

October 2015. HIFU for Palliative Treatment of Pancreatic Cancer. Khokhlova TD, Hwang JH. Adv Exp Med Biol. 2016;880:83-95. doi: 10.1007/978-3-319-22536-4_5.

September 2015. Pulsed high intensity focused ultrasound (pHIFU) enhances delivery of doxorubicin in a preclinical model of pancreatic cancer. Li T, Wang YN, Khokhlova TD, D'Andrea S, Starr F, Chen H, McCune JS, Risler LJ, Mashadi-Hossein A, Hwang JH. Cancer Res. 2015 Sep 15;75(18):3738-46. doi: 10.1158/0008-5472.CAN-15-0296. Epub 2015 Jul 27.

June 2015. Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease. Nazer B, Ghahghaie F, Kashima R, Khokhlova T, Perez C, Crum L, Matula T, Hata A. Circ J. 2015;79(9):2043-9. doi: 10.1253/circj.CJ-15-0366. Epub 2015 Jun 9.

May 2015. Endoscopic high-intensity focused US: technical aspects and studies in an in vivo porcine model (with video). Li T, Khokhlova T, Maloney E, Wang YN, D'Andrea S, Starr F, Farr N, Morrison K, Keilman G, Hwang JH. Gastrointest Endosc. 2015 May;81(5):1243-50. doi: 10.1016/j.gie.2014.12.019. Epub 2015 Mar 7.

March 2015. Histotripsy methods in mechanical disintegration of tissue: towards clinical applications. Khokhlova VA, Fowlkes JB, Roberts WW, Schade GR, Xu Z, Khokhlova TD, Hall TL, Maxwell AD, Wang YN, Cain CA. Int J Hyperthermia. 2015 Mar;31(2):145-62. doi: 10.3109/02656736.2015.1007538. Epub 2015 Feb 24. Review.

October 2014. A new active cavitation mapping technique for pulsed HIFU applications--bubble Doppler. Li T, Khokhlova TD, Sapozhnikov OA, O'Donnell M, Hwang JH. IEEE Trans Ultrason Ferroelectr Freq Control. 2014 Oct;61(10):1698-708. doi: 10.1109/TUFFC.2014.006502.

September 2014. Pulsed focused ultrasound treatment of muscle mitigates paralysis-induced bone loss in the adjacent bone: a study in a mouse model. Poliachik SL, Khokhlova TD, Wang YN, Simon JC, Bailey MR. Ultrasound Med Biol. 2014 Sep;40(9):2113-24. doi: 10.1016/j.ultrasmedbio.2014.02.027. Epub 2014 May 21.

July 2014. Passive Cavitation Detection during Pulsed HIFU Exposures of Ex Vivo Tissues and In Vivo Mouse Pancreatic Tumors. Li T, Chen H, Khokhlova T, Wang YN, Kreider W, He X, Hwang JH. Ultrasound Med Biol. 2014 Jul;40(7):1523-34. doi: 10.1016/j.ultrasmedbio.2014.01.007. Epub 2014 Mar 6.

June 2014. Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model. Khokhlova TD, Wang YN, Simon JC, Cunitz BW, Starr F, Paun M, Crum LA, Bailey MR, Khokhlova VA. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8161-6. doi: 10.1073/pnas.1318355111. Epub 2014 May 19.

May 2013. The use of twinkling artifact of Doppler imaging to monitor cavitation in tissue during high intensity focused ultrasound therapy. Khokhlova TD, Li T, Sapozhnikov OA, Hwang JH. J Acoust Soc Am. 2013 May;133(5):3315. doi: 10.1121/1.4805522.

March 2013. Histological and Biochemical Analysis of Mechanical and Thermal Bioeffects in Boiling Histotripsy Lesions Induced by High Intensity Focused Ultrasound. Wang YN, Khokhlova T, Bailey M, Hwang JH, Khokhlova V. Ultrasound Med Biol. 2013 Mar;39(3):424-38. doi: 10.1016/j.ultrasmedbio.2012.10.012. Epub 2013 Jan 11.

January 2013. Rectified growth of histotripsy bubbles. Kreider W, Maxwell AD, Khokhlova T, Simon JC, Khokhlova VA, Sapozhnikov O, Bailey MR. Proc Meet Acoust. 2013;19(1). pii: 075035.

June 2012. Temperature dependence of the optoacoustic transformation efficiency in ex vivo tissues for application in monitoring thermal therapies. Nikitin SM, Khokhlova TD, Pelivanov IM. J Biomed Opt. 2012 Jun;17(6):061214. doi: 10.1117/1.JBO.17.6.061214.

September 2011. HIFU for palliative treatment of pancreatic cancer. Khokhlova TD, Hwang JH. J Gastrointest Oncol. 2011 Sep;2(3):175-84. doi: 10.3978/j.issn.2078-6891.2011.033.

January 2011. Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling. Khokhlova TD, Canney MS, Khokhlova VA, Sapozhnikov OA, Crum LA, Bailey MR. J Acoust Soc Am. 2011 Nov;130(5):3498-510. doi: 10.1121/1.3626152.

April 2009. Magnetic resonance imaging of boiling induced by high intensity focused ultrasound. Khokhlova TD, Canney MS, Lee D, Marro KI, Crum LA, Khokhlova VA, Bailey MR. J Acoust Soc Am. 2009 Apr;125(4):2420-31. doi: 10.1121/1.3081393.

January 2007. Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics. Khokhlova TD, Pelivanov IM, Kozhushko VV, Zharinov AN, Solomatin VS, Karabutov AA. Appl Opt. 2007 Jan 10;46(2):262-72.

Contact Info

Senior Research Fellow, Division of Gastroenterology, School of Medicine, University of Washington, Seattle, WA (Joint with Center for Industrial and Medical Ultrasound)

Postdoctoral Fellow, Division of Gastroenterology, School of Medicine, University of Washington, Seattle, WA (Joint with Center for Industrial and Medical Ultrasound)

M.V., Lomonosov Moscow State University, Moscow, Russia

Ph.D., Physics, Lomonosov Moscow State University, Moscow, Russia

M.S., Physics (Cum Laude), Lomonosov Moscow State University, Moscow, Russia

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