- Colon cancer
under the age of 45 years
- Adenomas
under the age of 40 years
- Multiple
colonic malignancies (at the same time or sequentially)
- Multiple
primary cancers (colon and non-colon)
- >10
adenomas and a family history of colon cancer
- Families
with multiple closely related members who have had colon cancer
- Families
with colon cancer in more than one generation
- Clustering
of non-colon cancers in family members
(particularly stomach, breast, thyroid, and uterine).
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