Table 2a -- Treatment of volume depletion secondary to Nausea and Vomiting Mild Moderate - Severe Oral liquids -- 2-4 liters/day Oral electrolyte solutions (Gatorade, Pedialyte) IV isotonic fluids (0.9% saline) -- 1-2 liters over 1 hr, then based on monitoring of vital signs, urine output. Consider central venous or pulmonary capillary wedge pressure measurements to guide therapy. Monitor serum electrolytes -- replace K+ and Mg+ as needed.