Table 11 -- Drug treatment of nausea and vomiting
Drug Class Generic Name
(Trade Name)
Uses Recommended
Doses
Side Effects
Phenothiazines


Chlorpromazine
(Thorazine)
Uncommonly used for Nausea and Vomiting 10 - 25 mg q 4 - 6 po 
25mg q 3h IV slow
25-50 mg q 4h IM
100 mg q 6-8h pr
Hypotension

 
Prochlorperazine
(Compazine)
Nausea and vomiting 5-10 mg tid po
2.5 - 10 mg IV slow infusion
5-10 mg q 4h IM
25 mg bid pr
Hypotension
Prokinetics

Metoclopramide
(Reglan)

Cisapride
(Propulsid)

Trimethobenzamide
(Tigan)


Erythromycin

Bethanechol
Gastroparesis


GERD


Nausea and
vomiting


Gastroparesis

Gastroparesis
10-20 mg qid po
10-20 mg IV

10-20 mg qid po


250 mg tid/qid po
200 mg tid/qid IM
200 mg tid/qid pr

250 mg qid IV or po

10-25 mg qid po

Extrapyramidal symptoms

Abd pain, diarrhea
Drowsiness

Diarrhea, abd pain



Abd pain

Abd pain

Antihistamines

Dymenhydrinate
(Dramamine)

Meclizine
(Antivert)


Cyclizine
(Marezine)


Promethazine
(Phernagen)




Dyphenhydramine
(Benadryl)
Motion  sickness


Motion sickness



Meniere's disease



Motion Sickness





Motion Sickness


50 mg q 4h po


50 mg q 24h po



50 mg q 4h po
50 mg q 4h IV


25 mg q 12h po
25 mg q 12h IV
12.5-50 mg q 12h IM
12.5-50 mg q 12h pr


25-50 mg q 6h po
Drowsiness


Drowsiness



Drowsiness



Drowsiness





Drowsiness
Butyrophenones

Droperidol Post-op 2.5-5 mg IV Hypotension
Sedation
Extrapyramidal symptoms


 
Haloperidol Rarely used 0.5-2 mg po Hypotension
Sedation
Extrapyramidal symptoms
Anticholinergics

Scopolomine
(Transderm patch)
Motion Sickness 1.5 mg patch q 3 days
delivers 0.5g/day
Drowsiness
5-HT3 Receptor Antagonists

Ondansetron
(Zofran)

Granisetron
(Kytril)
Post-op
Chemotherapy

Chemotherapy
4 - 8 mg IV
32 mg one time dose

1 mg bid po
10 mcg/kg IV
Elevated LFTs


Headache
Non-pharmacological

Acupressure ? Motion Sickness

? Pregnancy