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David M. Hockenbery, MD

Professor
Member & Head, Gastroenterology & Hepatology Section, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance



Contact Information

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue, Seattle, WA, 98109
UW Box Number: 358080
Unit: FHCRC Clinical Research
P: (206) 667-4611
F: (206) 667-6519
dhockenb@u.washington.edu

Research & Clinical Interests

The bcl-2 oncogene and its role in apoptosis, mitochondrial biology and bioenergetic metabolism. Utilizes cell culture, transgenic mouse and protein biochemistry approaches for identification of cancer-selective metabolic pathways and discovery of small molecule inhibitors targeting these pathways.

Representative Publications

Tzung S-P, Kim K, Basanez G, Giedt C, Simon J, Zimmerberg J, Zhang K, Hockenbery DM. Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. Nature Cell Biol. 3: 183-191, 2001

Morrish F, Giedt C, Hockenbery DM. C-MYC apoptotic function is mediated by NRF-1 target genes. Genes and Development, 17: 240-255, 2003

O'Neill JW, Manion MK, Maguire B, Hockenbery DM. BCL-XL dimerization by three-dimensional domain swapping. J Mol Biol 356: 367-81, 2006

Schwartz PS, Manion MK, Emerson CB, Fry JS, Schulz CM, Sweet IR, Hockenbery DM. 2-methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition. Mol Cancer Ther, 6:2073-80, 2007.

Margineantu DH, Emerson CB, Diaz D, Hockenbery DM. Hsp90 inhibition decreases mitochondrial protein turnover. PLoS One, 2:e1066, 2007.

Morrish F, Isern N, Sadilek M, Jeffrey M, Hockenbery DM. C-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry. Oncogene 28:2485-91, 2009. PMCID: PMC2779836.



Education

M.D., Washington University, St. Louis, MO

Residency in Medicine, Johns Hopkins, Baltimore, MD

Fellowship in Gastroenterology, Washington University, St. Louis, MO

Fellowship in Molecular Oncology, Washington University, St. Louis, MO

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